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 Peptide Therapy

What are Peptides?

Peptides can be thought of as small proteins that act as highly specific signaling molecules in many crucial functions in our bodies. They assist in hormone production, cell signaling, and cell-to-cell communication. Researchers and clinicians alike are looking at peptides as a breakthrough in medicine because they have:

  • Low toxicity
  • High chemical and biological diversity
  • High potency and specificity
  • Good efficacy, safety, and tolerability
  • Broad range of targets
  • Enhances cell growth

We have incorporated peptides into our regenerative medicine program to enhance the overall effect of our stem cells therapies. Stem cells rely on healthy communication patterns from one cell to the next and are dependent on sending and receiving signals throughout the body. Peptides help to clean up the communication and signaling pathways via the cell receptors. The also improve the structure of cells by improving the availability of cellular material 

Poor health, diet, exposure to toxins, infections, electromagnetic radiation, injuries and illness can all alter the cells environment (niche) and disrupt this important cell to cell communication.

The peptides we utilize come from compounding pharmacies here in the United States. For more information regarding these pharmacies, please click these links.

Tailor Made Compounding

Wells Pharmacy Network 

What Might Peptides Help With? 

Peptides can be used to help people that may have symptoms associated with acute and chronic conditions and injuries.  The list of potential conditions that can benefit from peptide therapy is nearly endless, since Here is just a list of a few conditions that peptides may be able help: 

Acute and chronic injuries
Inflammation
Muscle strains and ligament sprains
Tendonitis
Joint and cartilage damage and degenerationCognitive impairment
Chronic infections
Inflammatory bowel disease
Traumatic Brain Injury TBI
Neurodegenerative conditions
Stem cell therapies
Fibromyalgia/Myalgia

 

  • Acute and chronic injuries
  • Inflammation
  • Muscle strains and ligament sprains
  • Tendonitis
  • Joint and cartilage damage and degeneration
  • Cognitive impairment
  • Chronic infections
  • Inflammatory bowel disease
  • Traumatic Brain Injury TBI
  • Neurodegenerative conditions
  • Stem cell therapies
  • Fibromyalgia/Myalgia

Some Types of Peptide Therapy Available

Wound Healing Peptides

BPC-157

– BPC 157 is a partial sequence of body protection compound (BPC) found in human gastric juice.
– BPC 157 can be used to accelerate healing of a variety of wounds including tendon-to bone healing and healing of damaged ligaments.
– Acts systematically in the digestive tract to combat leaky gut, IBS, gastro intestinal cramps and Crohn’s disease
– Protects and prevents gastric ulcers
– Can be used to protect liver from toxic damage (alcohol, antibiotics, etc.)
– Promotes healing of traumatic brain injury (TBI).
– Improves healing of many types of wounds
– Protects intestinal organs and prevents stomach ulcers
– Combats leaky gut, IBS, gastro-intestinal cramps and
Crohn’s disease
– Accelerate healing of skin burns
– Works as an anti-inflammatory
– Maintains integrity of mucosal lining GI tract
– Repairs tissues of GIT, tendons, ligaments, brain, bone, etc.
– Improves digestive function
– Protects and promotes healing of liver due to toxic stress.
– In response to tendon and ligament injury, BPC-157 accelerates healing by increasing type 1 collagen in these tissues.
– BPC-157 is cytoprotective and thus helps maintain the mucosal lining of the GI tract.
– As an anti-inflammatory, it aids in the protection and healing of inflamed intestinal tissues.
– BPC-157 also aids in tissue damage repair by increasing blood flow to damaged tissues.
– Additionally, BPC 157 acts as a neuroprotective by modulating serotonin and dopamine production in the brain.

Thymosin Beta 4 (Tꞵ4) AKA TB500

Thymosin beta 4 is also produced in the thymus gland and is also the predominant form of thymosin in the human body. This means it can be found in all human cells, although it is typically found in high concentrations in wound tissue and in certain blood cells involved in wound healing.

Despite being a peptide of only 43 amino acids, Tꞵ4 is involved in modulating a wide range of regenerative activities. When the wound healing process begins, Tꞵ4 aids in:

  • Promoting formation of new blood vessels to the injured area which carry essential reparative substances
  • Increasing “good” inflammation that can help the wound heal faster
  • Increasing the amount of cell-building proteins such as actin
  • Restoring tissue structure and metabolism
  • Promoting hair growth
  • Reducing acute/chronic wounds

AOD 9604

Initially known as an anti-obesity peptide, it is now being used more with increasing success for local pain: eg, tendonitis and osteoarthritis. Studies have shown that after destruction of joint cartilage of the knee, the combination of AOD 9604 with hyaluronic acid HA were able to significantly regenerate new cartilage and relieve lameness.

Immune Boosting Peptides

The benefits of peptides in areas like immune system function have been widely known for many years. Peptides can play a vital role when it comes to building immunity and strengthening the immune system’s response.  For centuries, our ancestors used natural defenses to protect themselves from diseases. Our bodies inherently know how to protect and defend themselves. 

Thymosins

The thymus gland is located behind your breastbone and between your lungs. Although it’s only active until puberty, it nevertheless plays a crucial role in the development of the immune system and in protecting the body against autoimmunity, a state in which the body’s immune system turns on itself. It is responsible for producing and secreting a hormone called thymosin, which stimulates the development of white blood cells called T-lymphocytes or T cells. For their roles in regulating the immune system, thymosins (also known as thymic peptides) are referred to as immune-modulatory peptides. 

There are two thymic peptides commonly used in peptide therapy: Thymosin alpha 1 (Tɑ1) and thymosin beta 4 (Tβ4). Both of these peptides have been shown to have important clinical applications, such as in modulating immune responses, neuroplasticity, blood vessel formation, etc. 

Thymosin Alpha 1 (Tɑ1)

Thymosin alpha 1 is a naturally-produced peptide of 28 amino acids that can enhance the body’s ability to recognize and respond to foreign invaders. At the cellular level, Tɑ1 interacts with proteins called Toll-Like Receptors (TLRs), and it is the interaction with TLRs on dendritic cells and precursor T cells that results in immune-stimulating effects, including:

  • Increased natural killer cell activity
  • Increased expression of TH1-type cytokines
  • Increased levels of cytotoxic T cells 
  • Reduced apoptosis of immune cells
  • A shift of T helper cells to Type 1 T helper (TH1) cells
  • Activation of dendritic cells 

Studies show that immune dysregulation and/or immunosenescence (gradual deterioration of the immune system associated with age) results in an imbalance of TH1 and TH2. TH1 and TH2 cells secrete proteins called cytokines that exhibit protective effects. TH1 cells produce interferon (IFN) -g and interleukin (IL)-2 which tend to be pro-inflammatory, while TH2 cells produce IL-4, IL-5, Il-6, IL-10, and IL-13 which are anti-inflammatory. 

TH1 and TH2 cells produce also differ in the types of immune responses they produce. TH1 cells typically deal with pathogens that get inside cells, such as bacteria and viruses. On the other hand, TH2 cells attack parasites from outside the cells as well as toxins and allergens. 

Both sides need to work together to have a well-balanced immune system. Neither should be in a dominant position. However, in some people, there is a prolonged period of time in which either TH1 or TH2 dominance occurs, leading to health problems. In particular, an increase in TH2 relative to TH1 has been linked to:

This is one of the most significant clinical applications of Tɑ1. As an immunomodulator, Tɑ1 restores balance to the body by increasing TH1 and decreasing TH2, thus breaking the cycle of immune dysfunction so often found in these illnesses.

Several clinical studies have shown that Tɑ1 may benefit a broad range of conditions, some of which include:

Due to the success of these clinical trials, peptides containing Tɑ1 have been approved for clinical use in over 35 countries (including the U.S.) and have had very few reports of adverse effects so far.

Thymosin Beta 4 (Tꞵ4)

Thymosin beta 4 is also produced in the thymus gland and is also the predominant form of thymosin in the human body. This means it can be found in all human cells, although it is typically found in high concentrations in wound tissue and in certain blood cells involved in wound healing. 

Despite being a peptide of only 43 amino acids, Tꞵ4 is involved in modulating a wide range of regenerative activities. When the wound healing process begins, Tꞵ4 aids in:

  • Promoting formation of new blood vessels to the injured area which carry essential reparative substances 
  • Increasing “good” inflammation that can help the wound heal faster
  • Increasing the amount of cell-building proteins such as actin 
  • Restoring tissue structure and metabolism
  • Promoting hair growth
  • Reducing acute/chronic wounds